Dohoon Lee

Postdoctoral fellow in computational biology/bioinformatics,
Bioinformatics Institute and BK21 FOUR Intelligence Computing, Seoul National University, South Korea.


Seoul National University

1 Gwanak-ro, Gwanak-gu

Seoul 08826, Republic of Korea

Hi! I’m Dohoon Lee. I got my Ph.D. from the Interdisciplinary Program in Bioinformatics at the Seoul National University, South Korea, as a member of Bio & Health Informatics Lab advised by professor Sun Kim. Before that I got my bachelor’s degree from the School of Biological Sciences at the Seoul National University, with a minor in Computer Science.

My research interests include computational epigenomics, especially the analysis of DNA methylation patterns within normal and malignant cells. I am deeply curious how the extent of errors in the somatic inheritance of DNA methylation states are systematically controlled. Recently, I am excited to examine the potential of deep learning architectures for the modeling of the complex interactions among chromatin features. I believe such AI-driven approaches will certainly be a new paradigm to pursue unbiased and novel scientific findings in a near future.

Besides, I also care about the reproducibility of research results and reusable analysis procedures. I implement it by modularizing routine analyses as self-contained analysis pipelines with workflow management tools, especially with snakemake!

Here you can see my CV in pdf.


Sep 14, 2022 🥈 Ranked 2nd in DREAM Challenge 2022: Predicting gene expression using millions of random promoter sequences
Aug 27, 2021 :mortar_board: Got Ph.D. in Bioinformatics at SNU
Jun 27, 2021 :desktop_computer: Ranked 34st (among ~4000 worldwide) in Bioinformatics Contest 2021. Enjoyed a lot!
Sep 23, 2020 :tada: Granted Youlchon AI for All fellowship by Youlchon Foundation, Korea
Sep 26, 2019 🥈 Earned Silver Medal (top 5%) in Kaggle Recursion Cellular Image Classification
Sep 7, 2019 🥈 Earned Silver Medal (top 4%) in Kaggle APTOS 2019 Blindness Detection
Aug 20, 2019 :tada: Outstanding paper award from BIOINFO 2019
Jun 21, 2019 :tada: Merit award (Bronze prize) from 45th annual meeting of Korean Cancer Association
Feb 24, 2019 :desktop_computer: Ranked 21st (among 3329 worldwide) in Bioinformatics Contest 2019!
Feb 25, 2018 :desktop_computer: Ranked 21st (among ~3000 worldwide) in Bioinformatics Contest 2018!

selected publications

  1. AMLs harboring DNMT3A-destabilizing variants show increased intratumor DNA methylation heterogeneity at bivalent chromatin domains
    Lee, Dohoon, Koo, Bonil, Kim, Seok-Hyun, Byun, Jamin, Hong, Junshik, Shin, Dong-Yeop, Sun, Choong-Hyun, Song, Ji-Joon, Kim, Jaesung, Jaiswal, Siddhartha, Yoon, Sung-soo, Kim, Sun, and Koh, Youngil
    bioRxiv 2023
  2. Learning the histone codes with large genomic windows and three-dimensional chromatin interactions using transformer
    Lee, Dohoon, Yang, Jeewon, and Kim, Sun
    Nature Communications 2022
  3. ISMB2019
    PRISM: methylation pattern-based, reference-free inference of subclonal makeup
    Lee, Dohoon, Lee, Sangseon, and Kim, Sun
    Bioinformatics 2019
  4. Towards multi-omics characterization of tumor heterogeneity: a comprehensive review of statistical and machine learning approaches
    Lee, Dohoon, Park, Youngjune, and Kim, Sun
    Briefings in bioinformatics 2021
  5. Learning the histone codes of gene regulation with large genomic windows and three-dimensional chromatin interactions using transformer
    Lee, Dohoon, Yang, Jeewon, and Kim, Sun
    bioRxiv 2021